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Respiratory disease

About

Respiratory diseases are one of the top three causes of mortality and hospitalisation in Malaysia. However, the disease burden, diagnosis, and management of chronic respiratory diseases (CRD) are unknown. In primary care, COVID-19, pneumonia and influenza are respiratory infections that usually present acutely but could lead to long term sequelae. Asthma and chronic obstructive lung disease are the commonest chronic lung conditions managed at the primary care level. Although these diseases are common and caused a significant economic burden, not much research in respiratory diseases is conducted in Malaysia. Good quality research on respiratory diseases is important and could lead to improvement in patient care.




Projects 

RESPIRE

RESPIRE is the National Institute of Health Research (NIHR) Global Health Research Unit at the University of Edinburgh that was funded as part of the NIHR Global Health Research Programme in 2016/2017. RESPIRE focuses on respiratory health and RESPIRE collaboration spans across Asia with organisations in Bangladesh, India, Malaysia and Pakistan. Department of Primary Care Medicine, University of Malaya is one of the main RESPIRE collaborators. There are 10 projects ranging from pilot studies, systematic reviews, scoping studies, evidence syntheses and health economics analyses to examine various aspects of asthma and chronic obstructive pulmonary disease (COPD).

Projects

  1. Developing and evaluating interventions at patient and practice level to improve asthma care (Klang Asthma)
  2. Exploring the provision of supportive care for patients with severe, potentially life-threatening COPD in Malaysia: a qualitative study of gaps and barriers, facilitators, and solutions from the perspective of patients, health care provider and policy makers (COPD Palliative Care)
  3. The asthma Hajj study (Malaysia and Bangladesh Hajj)
  4. Process for estimating chronic respiratory disease (asthma and COPD) burden in adults in Asian low and middle-income countries: A feasibility pilot [4CCORD Study - 4 Country Chronic Respiratory Disease Study]
  5. Air quality study: An ecological analysis of asthma health outcomes in Malaysia: a feasibility study (Air Quality Malaysia)
  6. Pulmonary rehabilitation program for patients with chronic respiratory diseases in Malaysia: A feasibility study (Pulmonary Rehabilitation)
  7. Exploring psychological issues of primary care team in Malaysia amidst COVID-19 pandemic (COVID PiPCAT)
  8. Strengthening rapid innovation research and implementation capacity in digital health in response to COVID-19, in Low- and Middle- Income countries (COVID eHealth)
  9. Fellowship: Developing patient and public involvement in research in Malaysia
  10. PhD: Culturally tailored school-based intervention for asthma in Malaysia

Researchers

Professor Dr Khoo Ee Ming, Associate Professor Dr Nik Sherina Hanafi, Associate Professor Dr Norita Hussein, Associate Professor Dr Adina Abdullah, Dr Siti Nurkamilla Ramdzan, Dr Rizawati Ramli

Publications

  1. Rudan, I., Agrawal, D., Hussein, N., Cheong, A. T., Cunningham, S., Dockerell, D., Ghazali, S. S., Ghorpade, D., Habib, M., Hazir, T., Juvekar, S., Kawade, A., Lee, P. Y., Liew, S. M., Luz, S., Khoo, E. M., Nair, H., Norrie, J., Patil, R., Pinnock, H., Ramdzan, S.N., Roy, S., Salim, H., Smith, Pam., Yahya, H.M., Williams, S., Campbell, H.,Sheikh, A. (2018). Setting research priorities for global respiratory medicine within the National Institute for Health Research (NIHR) Global Health Research Unit in Respiratory Health (RESPIRE). Journal of global health, 8(2), 0201314. https://doi.org/10.7189/jogh.08.020314
  2. Sheikh, A., Campbell, H., Balharry, D., Baqui, A. H., Bogaert, D., Cresswell, K., Cunningham, S., Dockerell, D., El Arifeen, S., Fletcher, M., Grant, L., Ghazali, S. S., Habib, M., Hazir, T., Isaac, R., Juvekar, S., Khoo, E. M., McKinstry, B., Morris, A. D., Nair, H., Norrie, J., Nwaru, I. B., Pinnock, H., Robertson, D., Saha, S., Salvi, S., Schwarze, J., Simpson, C., Sridhar, S., Stoddart, A., Weller, D., Whyte, M., Worth, A., William, S., Yusuf, O., Zumla, A., Rudan, I., RESPIRE Collaboration (2018). RESPIRE: The National Institute for Health Research's (NIHR) Global Respiratory Health Unit. Journal of global health, 8(2), 020101. https://doi.org/10.7189/jogh.08.020101
  3. Liew, S. M., Hussein, N., Hanafi, N. S., Pinnock, H., Sheikh, A., & Khoo, E. M. (2018). Dangers of COPD and asthma under-recognised among Hajj pilgrims. The Lancet Respiratory Medicine. http://dx.doi.org/10.1016/. S2213-2600(18)30297-2  
  4. Agarwal, D., Hanafi, N. S., Chippagiri, S., Brakema, E. A., Pinnock, H., Khoo, E. M., Sheikh, A., Liew, S. M., Ng, C. W., Isaac, R., Chinna, K., Ping, W. L., Hussein, N. B., Juvekar, S., & RESPIRE Collaborators (2019). Systematic scoping review protocol of methodologies of chronic respiratory disease surveys in low/middle-income countries. NPJ primary care respiratory medicine, 29(1), 17. https://doi.org/10.1038/s41533-019-0129-7
  5. Hanafi, N. S., Agarwal, D., Chippagiri, S., Brakema, E. A., Pinnock, H., Sheikh, A., Liew, S. M., Ng, C. W., Isaac, R., Chinna, K., Wong, L. P., Hussein, N., Abu Bakar, A. I., Pang, Y. K., Juvekar, S., & Khoo, E. M. (2021). Chronic respiratory disease surveys in adults in low- and middle-income countries: A systematic scoping review of methodological approaches and outcomes. Journal of global health, 11, 04026. https://doi.org/10.7189/jogh.11.04026
  6. Ramdzan, S. N., Pinnock, H., Liew, S. M., Sukri, N., Salim, H., Hanafi, N. S., Hussein, N., Suhaimi, J., Lee, P. Y., Cheong, A. T., Ahad, A. M., Cunningham, S., & Khoo, E. M. (2019). Perceptions of complementary/alternative medicine use and influence on evidence-based asthma medicine adherence in Malaysian children. NPJ primary care respiratory medicine, 29(1), 5. https://doi.org/10.1038/s41533-019-0118-x
  7. Salim, H., Young, I., Shariff Ghazali, S., Lee, P. Y., Ramdzan, S. N., & Pinnock, H. (2019). Protocol for a systematic review of interventions addressing health literacy to improve asthma self-management. NPJ primary care respiratory medicine, 29(1), 18. https://doi.org/10.1038/s41533-019-0125-y
  8. Ramdzan, S. N., Khoo, E. M., Liew, S. M., Cunningham, S., Kendall, M., Sukri, N., Salim, H., Suhaimi, J., Lee, P. Y., Cheong, A. T., Hussein, N., Hanafi, N. S., Mohd Ahad, A., & Pinnock, H. (2020). How young children learn independent asthma self-management: a qualitative study in Malaysia. Archives of disease in childhood, 105(9), 819–824. https://doi.org/10.1136/archdischild-2019-318127
  9. Ramdzan, S. N., Suhaimi, J., Harris, K. M., Khoo, E. M., Liew, S. M., Cunningham, S., & Pinnock, H. (2021). School-based self-management interventions for asthma among primary school children: a systematic review. NPJ primary care respiratory medicine, 31(1), 18. https://doi.org/10.1038/s41533-021-00230-2
  10. Koh, W. M., Abu Bakar, A. I., Hussein, N., Pinnock, H., Liew, S. M., Hanafi, N. S., Pang, Y. K., Ho, B. K., Mohamed Isa, S., Sheikh, A., & Khoo, E. M. (2021). Sociocultural influences on asthma self-management in a multicultural society: A qualitative study amongst Malaysian adults. Health expectations: an international journal of public participation in health care and health policy, 24(6), 2078–2086. https://doi.org/10.1111/hex.13352
  11. Chan, S. C., Sekhon, J. K., Engkasan, J. P., Nathan, J. J., Mirza, F. T., Liew, S. M., Hussein, N., Suhaimi, A., Hanafi, N. S., Pang, Y. K., Yatim, S. M., Jackson, T., Fernandes, G., Habib, G., Pinnock, H., Khoo, E. M., & RESPIRE Collaborators (2021). Barriers and challenges of implementing pulmonary rehabilitation in Malaysia: Stakeholders' perspectives. Journal of global health, 11, 02003. https://doi.org/10.7189/jogh.11.02003
  12. Cheong, A. T., Lee, P. Y., Shariff-Ghazali, S., Salim, H., Hussein, N., Ramli, R., Pinnock, H., Liew, S.M., Hanafi, N.S., Bakar, A.I.A., Mohd Ahad, A., Pang, Y.K., Chinna, K., Khoo, E. M. (2021). Implementing asthma management guidelines in public primary care clinics in Malaysia. NPJ primary care respiratory medicine, 31(1), 47. https://doi.org/10.1038/s41533-021-00257-5
  13. Lee, P. Y., Cheong, A. T., Ghazali, S. S., Salim, H., Wong, J., Hussein, N., Ramli, R., Pinnock, H., Liew, S.M., Hanafi, N.S., Bakar, A.I.A., Mohd Ahad, A., Pang, Y.K., Chinna, K.,Khoo, E. M. (2021). Barriers to implementing asthma self-management in Malaysian primary care: qualitative study exploring the perspectives of healthcare professionals. NPJ primary care respiratory medicine, 31(1), 38. https://doi.org/10.1038/s41533-021-00250-y
  14. Agarwal, D., Hanafi, N. S., Khoo, E. M., Parker, R. A., Ghorpade, D., Salvi, S., Abu Bakar, A. I., Chinna, K., Das, D., Habib, M., Hussein, N., Isaac, R., Islam, M. S., Khan, M. S., Liew, S. M., Pang, Y. K., Paul, B., Saha, S. K., Wong, L. P., Yusuf, O. M., Yusuf, S.O., Juvekar, S., Pinnock, H., RESPIRE Collaboration (2021). Predictors for detecting chronic respiratory diseases in community surveys: A pilot cross-sectional survey in four South and South East Asian low- and middle-income countries. Journal of global health, 11, 04065. https://doi.org/10.7189/jogh.11.04065
  15. Salim, H., Ramdzan, S. N., Ghazali, S. S., Lee, P. Y., Young, I., McClatchey, K., Pinnock, H., & NIHR Global Health Research Unit on Respiratory Health (RESPIRE) collaborations (2020). A systematic review of interventions addressing limited health literacy to improve asthma self-management. Journal of global health, 10(1), 010427. https://doi.org/10.7189/jogh.10.010428
  16. Ramdzan SN, Khoo EM, Liew SM on behalf of RESPIRE collaborators, et al. Stakeholders’ views of supporting asthma management in schools with a school-based asthma programme for primary school children: a qualitative study in Malaysia. BMJ Open 2022; 12:e052058. https://doi: 10.1136/bmjopen-2021-052058

Grant

  1. International grant: RESPIRE (IF028-2018)

Other projects

There are also other research projects in respiratory disease which was conducted by members of the department. Many of the projects were a collaboration with other departments and universities.

Researcher

Associate Professor Dr Nik Sherina Hanafi

Publications

  1. Ng KT, Oong XY, Lim SH, Chook JB, Takebe Y, Chan YF, Chan KG, Hanafi NS, Pang YK, Kamarulzaman A, Tee KK. Viral load and sequence analysis reveal the symptom severity, diversity, and transmission clusters of rhinovirus infections. Clinical Infectious Diseases. 2018 Jul 2;67(2):261-8.
  2. Oong XY, Chook JB, Ng KT, Chow WZ, Chan KG, Hanafi NS, Pang YK, Chan YF, Kamarulzaman A, Tee KK. The role of human Metapneumovirus genetic diversity and nasopharyngeal viral load on symptom severity in adults. Virology journal. 2018 Dec;15(1):1-1.
  3. Wong PL, Sii HL, P'ng CK, Ee SS, Yong Oong X, Ng KT, Hanafi NS, Tee KK, Tan MP. The effects of age on clinical characteristics, hospitalization and mortality of patients with influenzarelated illness at a tertiary care centre in Malaysia. Influenza and other respiratory viruses. 2020 May;14(3):286-93.
  4. Ng KT, Oong XY, Lim SH, Chook JB, Takebe Y, Chan YF, Chan KG, Hanafi NS, Pang YK, Kamarulzaman A, Tee KK. Viral load and sequence analysis reveal the symptom severity, diversity, and transmission clusters of rhinovirus infections. Clinical Infectious Diseases. 2018 Jul 2;67(2):261-8.

Researcher

Dr Nurdiana Abdullah

Publication

  1. Koh MT, Liu CS, Chiu CH, Boonsawat W, Watanaveeradej V, Abdullah N, Zhang X, Devadiga R, Chen J. Under-recognized pertussis in adults from Asian countries: a cross-sectional seroprevalence study in Malaysia, Taiwan and Thailand. Epidemiology & Infection. 2016 Apr;144(6):1192-200.

Researcher

Dr Nurdiana Abdullah, Associate Professor Adina Abdullah, Professor Khoo Ee Ming and Professor Chia Yook Chin

Publication

  1. Wong SS, Abdullah N, Abdullah A, Liew SM, Ching SM, Khoo EM, Jiwa M, Chia YC. Unmet needs of patients with chronic obstructive pulmonary disease (COPD): a qualitative study on patients and doctors. BMC family practice. 2014 Dec;15(1):1-8.